Unopened cream that has been left out at room temperature for an extended period of time, especially overnight, is at risk of spoilage. Bacteria can grow rapidly in dairy products when they are left unrefrigerated, potentially leading to foodborne illness [1].

Here are some key points to consider:

1. Perishable nature: Cream is a perishable dairy product and should be stored in the refrigerator to maintain its freshness and quality [2].
2. Time limit: Cream should not be left out at room temperature for more than two hours to minimize the risk of spoilage [2].
3. Temperature sensitivity: Cream can spoil in as little as one hour if left out in temperatures exceeding 90 degrees Fahrenheit [2].
4. Unopened containers: Even if the cream is unopened, it is still susceptible to spoilage if not refrigerated [2].
5. Signs of spoilage: If the cream has a strong sour or fermented smell, shows signs of mold, does not whip properly, or has an off taste, it is likely spoiled and should not be consumed [2].

To ensure food safety, it is important to follow proper storage guidelines for dairy products like cream. Refrigeration helps to slow down bacterial growth and maintain the quality of the cream.

Learn more:

1. Is the cream still good if it was left out all night, unopened, but ...
2. How Long Can Heavy Whipping Cream Be Left Out | Treat Dreams
3. Heavy Cream Left Out - CakeCentral.com